Artifacts spawned by anomalies are usually invisible until a Detector is used by the player, but occasionally an artifact can be seen jumping about in an anomaly field from a distance. There is only 1 artifact that the player must collect and that is the Compass Artifact, from Forester, as part of the main game mission. It is possible to play the game without collecting the artifacts but collecting and selling the artifacts, does make it easier to purchase and upgrade the armour, weapons and other items needed to survive.
There are 56 Artifacts of 25 different types that can be collected in the game.